In 2020, when the unexpected Covid-19 pandemic happened, scientists started working hard to find a vaccine. Many people were stuck at home, hoping for a solution. Luckily, researchers found a vaccine in just a few months, even with so many people dying.

But some scientists were worried. They thought the vaccines were being rushed out too quickly and that safety checks were being ignored. They believed it was important to make sure the vaccines would be safe for everyone in the long run.

Yesterday, AstraZeneca, a big company that made a Covid-19 vaccine, admitted in court papers for the first time that their vaccine might cause a rare and serious side effect called Thrombosis with Thrombocytopenia syndrome (TTS). Their vaccine, known as Covishield and Vaxzevria, has been given to lots of people worldwide, especially in India.

 

What is the AstraZeneca Covid-19 vaccine?

The AstraZeneca vaccine, also called AZD1222 or Covishield in India, is a type of vaccine made to protect against the virus that causes Covid-19, called SARS-CoV-2.

 

How does the Covishield vaccine work?

It uses a weakened form of a cold virus (adenovirus) found in chimpanzees. This virus is changed to carry a protein from the SARS-CoV-2 virus. When someone gets the vaccine, it helps their immune system make antibodies and activate T-cells. These help the body fight the virus if they’re exposed to it later on.

 

How was the AstraZeneca vaccine developed?

The AstraZeneca vaccine was developed through a collaboration between the University of Oxford and the British-Swedish pharmaceutical company AstraZeneca. Researchers at the University of Oxford had been developing a vaccine platform using adenovirus vectors for several years, and when the COVID-19 pandemic emerged, they quickly pivoted their efforts toward creating a vaccine against the novel coronavirus.

 

India’s role in AstraZeneca vaccine development

Pune-based pharma firm Serum Institute of India (SII) entered into a strategic partnership with AstraZeneca and the University of Oxford in January 2021 to manufacture the Covishield vaccine for India and other low- and middle-income countries.

Leveraging its extensive manufacturing capabilities and expertise in vaccine production, this partnership allowed SII to produce the vaccine at scale to meet the enormous demand in India and globally.

 

 

Distribution of Covishield in India

The distribution of Covishield in India has been facilitated through collaboration with the Government of India and various state governments, as well as through international partnerships such as COVAX, a global initiative aimed at equitable access to COVID-19 vaccines.

 

As of 2022, over 1.7 billion doses of Covishield were administered in India as part of the world’s largest vaccination program.

The AstraZeneca vaccine, with its relatively simple storage requirements (it can be stored for up to 6 months) and widespread availability, has played a crucial role in vaccination campaigns worldwide, including India’s efforts to curb the spread of COVID-19 and achieve herd immunity.

 

 

What were the side effects of the Covishield vaccine?

The World Health Organisation lists the side effects of the AstraZeneca vaccine, including mild to moderate symptoms that are typically short-term and self-limiting.

Common side effects reported after receiving the AstraZeneca vaccine were discomfort at the injection site, feeling generally unwell, tiredness, fever, headache, feeling sick, joint or muscle pain, swelling, redness at the injection site, dizziness, sleepiness, sweating, abdominal pain, and fainting.

 

These side effects were said to be usually temporary and resolved without the need for hospitalization.

 

Where was the AstraZeneca Covid-19 vaccine banned?

Following scrutiny of the AstraZeneca vaccine, the product was banned in several countries. Denmark was the first country to suspend Covid-19 vaccine AstraZeneca, and Ireland, Thailand, the Netherlands, Norway, Iceland, Congo, and Bulgaria soon followed suit.

European countries, including Germany, France, Italy, and Spain, also stopped using AstraZeneca’s Covid-19 vaccine in 2021 after multiple cases of blood clots were reported in patients who were administered the vaccine.

Canada, Sweden, Latvia, and Slovenia joined the league in banning the use of the vaccine in the same year. The vaccine was further banned in Australia, Indonesia, and Malaysia due to public concerns about its safety.

 

However, the World Health Organization (WHO) soon stated in March regarding the AstraZeneca Covid-19 vaccine safety signals and still considered the vaccine’s benefits to outweigh its potential risks, further recommending that vaccinations continue.

 

What is the new AstraZeneca controversy?

In court documents submitted to a UK court in February, the AstraZeneca company stated that a rare side effect known as Thrombosis with Thrombocytopenia Syndrome (TTS) can occur. It said, “It is admitted that the AZ vaccine can, in very rare cases, cause TTS. The causal mechanism is not known.”

However, in the papers, it also said that even if there is no vaccination TTS can happen, adding that expert testimony will be required to determine causation in every individual case.

 

The Cambridge-headquartered British-Swedish multinational pharmaceutical and biotechnology company now faces a class-action lawsuit, which claims that its vaccine caused serious injuries and fatalities.

 

What is TTS, the condition associated with the Covishield vaccine?

Thrombosis with Thrombocytopenia syndrome (TTS) is a rare but serious condition associated with certain COVID-19 vaccines, particularly adenovirus vector vaccines such as the AstraZeneca vaccine and Johnson & Johnson’s Janssen vaccine. TTS involves the formation of blood clots in combination with low platelet levels (thrombocytopenia).

The condition typically presents itself with blood clots occurring in unusual locations, such as the brain (cerebral venous sinus thrombosis) or abdomen, along with low platelet counts. The symptoms of TTS include severe headache, blurred vision, difficulty speaking, chest pain, abdominal pain, shortness of breath, and leg swelling, among others.

 

TTS has been thought to result from an immune response triggered by the adenovirus vector used in the vaccines, which activates platelets and forms blood clots.

 

 

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